Substance is often taken in larger amounts or over a longer period than was intended.

There is a persistent desire or unsuccessful efforts to cut down or control substance use.

A great deal of time is spent in activities necessary to obtain, use, or recover from its effects.

Craving, or a strong desire or urge to use the substance.

Recurrent substance use resulting in a failure to fulfill major role obligations at work, school, or home.

Continued substance use despite having persistent or recurrent social or interpersonal problems.

Important social, occupational, or recreational activities are given up or reduced because of substance use.

Recurrent substance use in situations in which it is physically hazardous.

Substance use is continued despite knowledge of having a persistent or recurrent physical or psychological problem.

Tolerance, as defined by either a need for markedly increased amounts or a markedly diminished effect.

Withdrawal, as manifested by either the characteristic withdrawal syndrome or substance use to relieve symptoms.